#  Light Scattering 

 



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   ![Wyatt Dynapro Plate Reader III](/sites/g/files/omnuum4016/files/styles/hwp_1_1__360x360_scale/public/2025-02/dynaproIII_crop_0.png?itok=latnUviO) 

 



 

 [### Dynamic light scattering

 ](/dynamic-light-scattering) 

 

   ![Wyatt SEC-MALS system](/sites/g/files/omnuum4016/files/styles/hwp_1_1__360x360_scale/public/2025-02/Wyatt_SEC_MALS_crop.png?itok=5i7uaCDp) 

 



 

 [### SEC-MALS

 ](/sec-mals) 

 

   ![Refeyn TwoMP](/sites/g/files/omnuum4016/files/styles/hwp_1_1__360x360_scale/public/2025-02/Refeyn%20TwoMP_crop.png?itok=vEPKa_gp) 

 



 

 [### Mass Photometry

 ](/mass-photometry) 

 

 

 

 

 

 

The CMI offers **Training and Access** on SEC-MALS, Mass Photometry and DLS instruments and select **Data Collection Services**.

[Dynamic Light Scattering (DLS)](/dynamic-light-scattering "Dynamic Light Scattering (DLS)") measures the time-dependent fluctuations in scattered light. These fluctuations are directly related to rate of diffusion of the molecule through the solvent, and can be used to measure hydrodynamic radius (Rh) of the particles in solution. ​​​​​​

[Size exclusion chromatography with multi-angle static light scattering (SEC-MALS)](/sec-mals "Size-Exclusion Chromatography with Multi-Angle Light Scattering (SEC-MALS)") is used to accurately measure weight-averaged masses (Mw) of macromolecules in solution by measure the intensity of scattered light of a sample as it elutes from an SEC column.

[Mass Photometry (MP)](/mass-photometry "Mass Photometry (MP)") is a single-particle light scattering method used to measure mass of macromolecules in solution, >30 KDa and for which standards with a shared refractive index are known (e.g. Protein or DNA).

 ![CMI light scattering technologies](/sites/g/files/omnuum4016/files/2025-04/CMI_Light_Scattering_Graphic.png)

 



 

 [ Light Scattering Services arrow\_circle\_right ](/light-scattering-services) [ About Data Collection Services arrow\_circle\_right ](/services) 

 

 

 

 

 



 

 See also:- [ molecular properties ](/cmi-terms/molecular-properties)
- [ Light Scattering ](/cmi-terms/light-scattering)
- [ Static Light Scattering ](/cmi-terms/static-light-scattering)
- [ Multi-Angle Light Scattering ](/cmi-terms/multi-angle-light-scattering)
- [ Mass Photometry ](/cmi-terms/mass-photometry)
- [ Dynamic Light Scattering ](/cmi-terms/dynamic-light-scattering)