#  Measuring Molecular Properties 

 



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   ![Jasco J-1500](/sites/g/files/omnuum4016/files/styles/hwp_1_1__360x360_scale/public/2025-02/j1500-crop.png?itok=GSpr6w_l) 

 



 

 [##### Circular Dichroism

 ](/circular-dichroism)CD is used to measure protein secondary structure, and thermal and chemical stability, by detecting optical isomerism



 

 

   ![DSF instruments](/sites/g/files/omnuum4016/files/styles/hwp_1_1__360x360_scale/public/2025-02/dsf_instruments_16x9.png?itok=lH-lO4eD) 

 



 

 [##### Differential Scanning Fluorimetry

 ](/differential-scanning-fluorimetry)DSF is used to assess thermal or chemical stability, by detecting fluorescence changes due to protein unfolding.



 

 

   ![light scattering instruments](/sites/g/files/omnuum4016/files/styles/hwp_1_1__360x360_scale/public/2025-02/light-scattering%20instruments%20_16x9.png?itok=w_bJ9Xpo) 

 



 

 [##### Light Scattering

 ](/light-scattering)Static Light Scattering methods (SEC-MALS, Mass Photometry) are used to measure mass and Dynamic Light Scattering (DLS) is used to measure radius, in solution.



 

 

 

 

 

 

 

The CMI has tools to characterize the physical properties of your protein or macromolecule. These can be used to compare proteins or to optimize purification and storage conditions.

- [Circular Dichroism](/circular-dichroism "Circular Dichroism (CD)") measures protein secondary structure, and thermal and chemical stability.
- [Differential Scanning Fluorimetry](/differential-scanning-fluorimetry "Differential Scanning Fluorimetry (DSF)") measures thermal stability or chemical stability, at higher throughput.
- [Light Scattering](/light-scattering "Light Scattering")
    
    
    - [Dynamic Light Scattering](/dynamic-light-scattering "Dynamic Light Scattering (DLS)") is used to measure hydrodynamic radius (or particle size).
    - [Mass Photometry](/mass-photometry "Mass Photometry (MP)") and [Size Exclusion chromatography with Multi-Angle Light Scattering](/sec-mals "Size-Exclusion Chromatography with Multi-Angle Light Scattering (SEC-MALS)") are Static Light Scattering techniques, used to measure molar mass in solution.



 

###  CMI Technologies to Measure Molecular Properties 

 ![CMI Technologies for Measuring Molecular Properties](/sites/g/files/omnuum4016/files/cmi/files/cmi_technologies_properties.png)

 

 ![CMI Technology Comparison Table - Properties](/sites/g/files/omnuum4016/files/2025-01/2025-properties-table.png)

 



 

 



 

 See also:- [ molecular properties ](/cmi-terms/molecular-properties)
- [ Circular Dichroism ](/cmi-terms/circular-dichroism)
- [ Differential Scanning Fluorimetry ](/cmi-terms/differential-scanning-fluorimetry)
- [ Light Scattering ](/cmi-terms/light-scattering)
- [ Static Light Scattering ](/cmi-terms/static-light-scattering)
- [ Multi-Angle Light Scattering ](/cmi-terms/multi-angle-light-scattering)
- [ Mass Photometry ](/cmi-terms/mass-photometry)
- [ Dynamic Light Scattering ](/cmi-terms/dynamic-light-scattering)