@article {Park2022.07.14.500081,
	title = {Cryo-EM structure of a RAS/RAF recruitment complex},
	journal = {bioRxiv},
	year = {2022},
	publisher = {Cold Spring Harbor Laboratory},
	abstract = {Cryo-EM structures of a KRAS/BRAF/MEK1/14-3-3 complex reveal KRAS bound to the flexible Ras-binding domain of BRAF, captured in two orientations. Autoinhibitory interactions are unperturbed by binding of KRAS and in vitro activation studies confirm that KRAS binding is insufficient to activate BRAF, absent membrane recruitment. These structures illustrate the separability of binding and activation of BRAF by Ras and suggest stabilization of this pre-activation intermediate as an alternative to blocking binding of KRAS.Competing Interest StatementThe authors have declared no competing interest.},
	doi = {10.1101/2022.07.14.500081},
	url = {https://www.biorxiv.org/content/early/2022/07/14/2022.07.14.500081},
	author = {Park, Eun Young and Rawson, Shaun and Schmoker, Anna and Kim, Byeong-Won and Oh, Sehee and Song, KangKang and Jeon, Hyesung and Eck, Michael}
}
