Center for Macromolecular Interactions

The Center for Macromolecular Interactions (CMI) in the department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School has a mission to enhance basic research in the HMS community by providing scientific consultation, training and access to shared biophysical instruments for the characterization and analysis of macromolecules and their complexes. 

The facility currently offers training and access to instruments for Isothermal Titration Calorimetry (ITC)Surface Plasmon Resonance (SPR)Biolayer Interferometry (BLI)MicroScale Thermophoresis (MST)Differential Scanning Fluorimetry (DSF)Circular Dichroism (CD), and Light Scattering: including size-exclusion chromatography with multi-angle light scattering (SEC-MALS), Dynamic Light Scattering (DLS), and Mass Photometry (MP)

The CMI offers data collection services for the characterization of protein secondary structure, mass and oligomeric state, polydispersity, aggregation state, hydrodynamic radius, and thermal stability.  Using a library developed in the lab of Andrew Kruse, the CMI is also offering yeast surface display nanobody selections services.