The Center for Macromolecular Interactions (CMI) in the department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School provides scientific consultation, training and access to shared biophysical equipment for the characterization and analysis of macromolecules and their complexes.

The facility currently includes instruments for Isothermal Titration Calorimetry (ITC), Surface Plasmon Resonance (SPR), Biolayer Interferometry (BLI), Differential Scanning Fluorimetry (DSF), Circular Dichroism (CD), Analytical Size Exclusion Chromatography for Multi-Angle Light Scattering (SEC-MALS) or Fluorescence detection (FSEC), and MicroScale Thermophoresis (MST).


The instruments in the CMI are available for use by all Harvard and HMS-affiliated academic laboratories.  Limited access may be give to users from unaffiliated academic labs and non-academic labs, at the discretion of the director.  To offset some of the cost of instrument maintenance, all users are charged access fees for training and use of CMI instruments.