Fees

All users are charged fees for training and access to CMI instruments.  Rates are reviewed biannually and posted here.  Invoices are generated at the end of each month and managed by the BCMP finance department and Harvard Accounts Receivable.  Fees are determined based on the primary institution of the user's Principal Investigator.  

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See also: Billing

Access Fees

  • Access fees are billed hourly or daily, depending on the instrument.  
  • Rates are billed by booked time and by real-time usage in excess of booked time.
  • Cancellations must be made at least 24 hours in advance to avoid booking fees.

Training Fees

  • An instrument training fee is charged per user per instrument.
  • Training may be individual or in small groups (2-5 people), as scheduling allows.
  • All training sessions include:
    • Overview of the instrument and maintenance procedures
    • Tutorial on control and analysis software
    • Review of experimental design
  • Training sessions do NOT include user data collection. 

FY23 Fees - Access and Training (effective July 1, 2022)

FY23 Harvard Access Fees

  • Users from labs with a primary appointment at Harvard Medical School or Harvard University are charged the base academic rates.  
  • Users are in this group if:
    • Harvard University administers the laboratory's grants  AND
    • the lab has a 33-digit code for internal billing

 

  • Instrument Access Fees (includes F&A) One-time per-person Training Fees
    SPR: Biacore T200 $504/day $648
    ITC: Microcal ITC200 $504/day $648
    MST: NanoTemper Monolith NT.115 $62/hour $459
    BLI: ForteBio Octet RED384 $62/hour $459
    BLI: ForteBio BLItz $62/hour $306
    CD: Jasco J-815 CD $50/hour $396
    DSF: Life Tech. Quant Studio 6 $50/hour $396
    DSF: NanoTemper Prometheus NT.Plex $50/hour $396
    Light Scattering: Wyatt DynaPro Plate Reader III $50/hour $396
    Light Scattering: Wyatt/Agilent SEC-MALS

    $31.5/hour 
    $504/day (max)

    $648

    Mass Photometry: Refeyn TwoMP $62/hour $420
    Initial consultation no charge  

 The SEC-MALS/FSEC system is billed in 4 hour blocks.

FY23 Academic Access Fees

  • Users from all non-Harvard academic labs are charged an additional Facilities and Administration Fee (F&A Fee) which goes to HMS to cover a portion of the facilities and administration costs for the CMI space.  The current F&A rate is 22%.
  • Academic Users are considered External if:
    • their lab's grants are managed by any institution other than Harvard University
    • their lab will NOT be paying with a Harvard 33-digit billing code
    • their lab is located at a affiliated Hospital (including BWH, Children's Hospital, Beth Isreal, DFCI, MGH) or other academic institution 
  • Users from academic institutions not affiliated with Harvard or Harvard Medical School will need to provide a PO number before access.
Instrument Access Fees (includes F&A) One-time per-person Training Fees
SPR: GE Biacore T200 $614.88/day $790.56
ITC: Microcal ITC200 $614.88/day $790.56
MST: NanoTemper Monolith NT.115 $75.64/hour $559.98
BLI: ForteBio Octet RED384 $75.64/hour $559.98
BLI: ForteBio BLItz $75.64/hour $373.32
CD: Jasco J-815 $61/hour $483.12
DSF: Life Tech. Quant Studio 6 $61/hour $483.12
DSF: NanoTemper Prometheus NT.Plex $61/hour $483.12
Light Scattering:
Wyatt Dynapro Plate Reader III
$61/hour $483.12
Light Scattering:
Wyatt/Agilent SEC-MALS

$38.43/hour
$614.88/day (max)

$790.56

Mass Photometry: Refeyn TwoMP $75.64/hour $512.40
Initial consultation no charge

 The SEC-MALS/FSEC system is billed in 4 hour blocks.

FY23 Commercial Access Fees

  • Non-academic access is granted on a case-by-case basis, by the CMI director
  • Priority access is given to Harvard-affiliates and academic users. 
  • Users from non-academic institutions will need to provide a PO number before access.
  • Harvard Life Lab companies are offered a 25% discount off the standard commercial rates.

For more information or to inquire about access, contact cmi@hms.harvard.edu.

 

Instrument Access Fees (includes F&A) One-time per-person Training Fees
SPR: Biacore T200 $1229.76/day $1581.12
ITC: Microcal ITC200 $1229.76/day $1581.12
MST: NanoTemper Monolith NT.115 $151.28/hour $1119.96
BLI: ForteBio Octet RED384 $151.28/hour $1119.96
BLI: ForteBio BLItz $122/hour $746.64
CD: Jasco J-815 $122/hour $966.24
DSF: Life Tech. Quant Studio 6 $122/hour $966.24
DSF: NanoTemper Prometheus NT.Plex $122/hour $966.24
Light Scattering:
Wyatt Dynapro Plate Reader III
$122/hour $966.24
Light Scattering:
Wyatt/Agilent SEC-MALS

$76.86/hour
$1229.76/day (max)

$1581.12

Mass Photometry: Refeyn TwoMP $151.28 $1024.80
Initial consultation no charge

 

 The SEC-MALS/FSEC system is billed in 4 hour blocks.

FY23 Fees - Data Collection (effective from July 1, 2022)

Data Collection Fees Summary

Data Collection Fees

  • Limited Data Collection Services are offered. Service fees will be charged for all completed services, regardless of experimental outcome. 
  • Before submitting samples for data collection, users must approve the estimated charges and be given a date and time for sample delivery.
    • External Users will also be required to submit a PO and a signed CMI User Agreement.
  • Most CMI Data Collection Services include a setup fee plus a per-sample data collection fee. Some services include one or more replicate measurements by default in the sample fee (e.g. DLS and DSF). For others, there may be reduced-price replicate measurement fee (e.g. SEC-MALS and CD) if collected in the same dataset.

Data Collection Fee List

Light Scattering Data Collection Fees

  Harvard base price Non-Harvard (+F&A) Commercial Life Lab
DLS - plate setup $270.00 $329.40 $658.80 $494.10
Setup fee per plate, up to 48 samples, includes BSA control and 1 buffer control. In addition to per-sample fee.
DLS - sample data collection - macromolecules $75.00 $91.50 $183.00 $137.25
Per sample fee, in duplicate wells, 5-10 acquisitions/scan, 2 scans/well, in addition to plate setup fee.
SEC-MALS -column setup  $450.00 $549.00 $1,098.00 $823.50
per buffer, includes analytical column equilibration, BSA control, in addtion to per-sample fee.
SEC-MALS data collection $250.00 $305.00 $610.00 $457.50
per sample, analytical column, 0.5 ml/min
SEC-MALS replicate injection  $110.00 $134.20 $268.40 $201.30
replicate sample injection collected in the same sequence
dn/dc measurement $455.00 $555.10 $1,110.20 $832.65
per user-provided reagent
SEC PBS Buffer preparation $65.00 $79.30 $158.60 $118.95
up to 1 L PBS buffer, filtered and degassed
SEC Custom Buffer preparation $160.00 $195.20 $390.40 $292.80
up to 1 L custom buffer, made using reagents available at the CMI (HEPES, Phosphate, NaCl, reducing agents)

DSF Data Collection Fees

  Harvard Non-Harvard (+F&A) Commercial Life Lab
base price
DSF thermal shift analysis -plate setup  $        275  $   335.50  $     671.00 503.25
Setup fee per plate, up to 30 samples, includes lysozyme control and 1 buffer control. DSF on the QuantStudio using SyproOrange protein stain. In addition to per-sample fee.
DSF sample data collection  $           70  $     85.40  $     170.80 128.1
Per sample fee, measured in triplicate, 2C/min, in addition to setup fee.
DSF buffer optimization screen  $        455  $   555.10  $  1,110.20 832.65
96 conditions NaCl vs pH, 1 measurement each, 2C/min
nanoDSF thermal shift analysis -setup  $        275  $   335.50  $     671.00 $     503.25
Setup fee per capillary set, up to 10 samples, includes lysozyme or BSA control. DSF on the Prometheus using protein fluorescence. In addition to per-sample fee.
nanoDSF sample data collection  $           70  $     85.40  $     170.80 $     128.10
Per sample fee, measured in duplicate, 2C/min, in addition to setup fee.
Per sample fee, measured in duplicate, 2C/min, PREMIUM CAPILLARIES (High Sensitivity Capillaries for low concentration) $           110 $     134.20 $     268.40 $     201.30
nanoDSF Buffer Optimization Screen  $        595  $   725.90  $  1,451.80 $   1088.85
96 conditions NaCl vs pH, 1 measurement each, 2C/min

 

CD Data Collection Fees

  Harvard base price Non-Harvard (+F&A) Commercial Life Lab
CD scan set up fee $195 $237.90 $475.80 $356.85
Setup fee per dataset (up to 20 scans), includes 1 buffer control. Additional buffers should be listed as samples.
CD scan for secondary structure $135 $164.70 $329.40 $247.05
Per sample, Far-UV 260-185 nm scan, 5-10 accumulations, in addition to setup fee.
CD replicate sample scan $70 $73.20 $146.40 $109.80
Replicate sample collected in the same dataset (or alternate temperature scan of existing sample)
CD thermal melt $510 $622.20 $1,244.40 $933.30
Per sample, 20-95C scan, 1C interval, 1C/min rate, 30s hold, 1-3 wavelengths, includes CD scan at 20C.

FY23 Example Project Fees

Example project details: Light Scattering analysis project for SEC-MALS of 2 proteins in one buffer system. Project setup includes column equilibration (12+ column volumes) into user-provided buffer and a BSA control experiment.  One additional replicate injection of each sample was requested.

line item Qty Internal price External Academic price
SEC-MALS setup  1 $450 $549.00
SEC-MALS data collection 2 2x $250 2x $305.00
SEC-MALS replicate injection 2 2x $110 2x $134.20
Total   $1,170 $1427.40

Nanobody Selection Fees

Please contact the CMI to start a conversation about nanobody selections.  Fees for Nanobody selections cover supplies and labor and are assessed for completed stages in the selection, regardless of final experimental outcome of the selection. 

Service

Harvard Internal

(33-digit)

External
Academic
Antigen Purification by SEC
Required if not completed by user
$650 $793.00
Yeast Surface Display Selection Campaign
Includes 2 rounds MACS, 2 rounds FACS and clonal isolation
delivery of any sequences or clones produced
$7980 $9735.60
Optional - Expression and Purification of Nanobody
1L scale, in e.coli pET26b, with 6-His tag
$4180 $5099.60
Total
includes selection campaign and nanobody expression
$12810 $15628.20

 

 

Contact Addresses

General Inquiries
and Questions

 
Kelly Arnett, Director
cmi@hms.harvard.edu
617-432-5004

 

Shipping Address: 

Harvard Medical School
240 Longwood Ave.
Building C, Room 309
Boston, MA 02115

 

Do not ship samples
without receiving 
specific instructions from
the CMI.

Billing Address:

Harvard University
PO BOX 4999

Boston, MA 02212-4999


ar_customers@harvard.edu

Pay a Bill

 

question about a bill:
Contact: Lola Yao 
Lola_Yao@hms.harvard.edu