Fees

All users are charged fees for training and access to CMI instruments.  Rates are reviewed biannually and posted here.  Invoices are generated at the end of each month and managed by the BCMP finance department and Harvard Accounts Receivable.  Fees are determined based on the primary institution (institution paying invoices) of the user's Principal Investigator.  

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See also: Billing

Access

  • Access fees are billed hourly or daily, depending on the instrument.  
  • Rates are billed by booked time and by real-time usage in excess of booked time.
  • Cancellations must be made at least 24 hours in advance to avoid booking fees.

Training

  • An instrument training fee is charged per user per instrument.
  • Training may be individual or in small groups (2-5 people), as scheduling allows.
  • All training sessions include:
    • Overview of the instrument and maintenance procedures
    • Tutorial on control and analysis software
    • Review of experimental design
  • Training sessions do NOT include user data collection. 

ACCESS AND TRAINING - FY24 FEES (EFFECTIVE JULY 1, 2023)

FY24 Harvard Access Fees

  • Users from labs with a primary appointment at Harvard Medical School or Harvard University are charged the internal academic rates.  
  • Users are in this group if:
    • Harvard University administers the laboratory's grants  AND
    • the lab has a 33-digit code for internal billing

 

Instrument Internal
Access Fee
Per-person
Training Fee
BLI: ForteBio Octet RED384 $66/hour $492
BLI: ForteBio BLItz $66/hour $328
MST: NanoTemper Monolith NT.115  $66/hour $492
SPR: Biacore T200 $540/day $648
ITC: Microcal ITC-200 $540/day $648
Mass Photometry:Refeyn TwoMP $66/hour $450
DLS: Wyatt DynaPro Plate Reader III $54/hour $420
SEC-MALS: Wyatt/Agilent SEC-MALS $33.75/hour $648
SEC-MALS: Wyatt/Agilent SEC-MALS $540/day (max)  
DSF: Life Technologies QuantStudio 6 $54/hour $420
DSF: NanoTemper Prometheus $54/hour $420
CD: Jasco J-1500 CD Spectrometer $54/hour $420
Chromatography: AKTA Pure $540/day $648

FY24 Academic Access Fees

  • Users from all non-Harvard academic labs are charged an additional Facilities and Administration Fee (F&A Fee) which goes to HMS to cover a portion of the facilities and administration costs for the CMI space.  The current F&A rate is 20%.
  • Academic Users are considered External if:
    • their lab's grants are managed by any institution other than Harvard University
    • their lab will NOT be paying with a Harvard 33-digit billing code
    • their lab is located at a affiliated Hospital (including BWH, Children's Hospital, Beth Isreal, DFCI, MGH) or other academic institution 
  • Users from academic institutions not affiliated with Harvard or Harvard Medical School will need to provide a PO number before access.

 

Instrument Academic
Access Fee
Per-person
Training Fee
BLI: ForteBio Octet RED384 $79.20/hour $590.40
BLI: ForteBio BLItz $79.20/hour $393.60
MST: NanoTemper Monolith NT.115  $79.20/hour $590.40
SPR: Biacore T200 $648/day $777.60
ITC: Microcal ITC-200 $648/day $777.60
Mass Photometry:Refeyn TwoMP $79.20/hour $540.00
DLS: Wyatt DynaPro Plate Reader III $64.80/hour $504.00
SEC-MALS: Wyatt/Agilent SEC-MALS $40.50/hour $777.60
SEC-MALS: Wyatt/Agilent SEC-MALS $648/day (max)  
DSF: Life Technologies QuantStudio 6 $64.80/hour $504.00
DSF: NanoTemper Prometheus $64.80/hour $504.00
CD: Jasco J-1500 CD Spectrometer $64.80/hour $504.00
Chromatography: AKTA Pure $648/day $777.60

 

FY24 Commercial Access Fees

  • Non-academic access is granted on a case-by-case basis, by the CMI director
  • Priority access is given to Harvard-affiliates and academic users. 
  • Users from non-academic institutions will need to provide a PO number before access.
  • Resident Harvard Life Lab companies are offered a 25% discount off the standard commercial rates.

For more information or to inquire about access, contact the CMI.

Instrument Commercial
Access Fee

Per-person
Training Fee

 BLI: ForteBio Octet RED384  $158.4/hour $1,180.80
 BLI: ForteBio BLItz  $158.4/hour $787.20
 MST: NanoTemper Monolith NT.115   $158.4/hour $1,180.80
 SPR: Biacore T200  $1296/day $1,555.20
 ITC: Microcal ITC-200  $1296/day $1,555.20
 Mass Photometry:Refeyn TwoMP  $158.4/hour $1,080.00
 DLS: Wyatt DynaPro Plate Reader III  $129.6/hour $1,008.00
 SEC-MALS: Wyatt/Agilent SEC-MALS  $81/hour $1,555.20
 SEC-MALS: Wyatt/Agilent SEC-MALS  $1296/day (max)
 DSF: Life Technologies QuantStudio 6  $129.6/hour $1,008.00
 DSF: NanoTemper Prometheus  $129.6/hour $1,008.00
 CD: Jasco J-1500 CD Spectrometer  $129.6/hour $1,008.00
 Chromatography: AKTA Pure  $1296/day $1,555.20

Data Collection

  • Limited Data Collection Services are offered.
  • Service fees are based on labor and supplies costs, and will be charged for all completed services, regardless of experimental outcome. 
  • Before submitting samples for data collection, users must approve the estimated charges and be given a date and time for sample delivery.
    • External Users will also be required to submit a PO and a signed CMI User Agreement.
  • Most CMI Data Collection Services include a setup fee plus a per-sample data collection fee.
    • Some services include replicate measurements by default in the per-sample fee. For others, there is a reduced-price replicate measurement fee, if collected in the same dataset.
  • Nanobody services not available to commercial users at this time.
  • Current Harvard Life Lab commercial users are offered a 25% discount off the standard commercial rates.

All Data Collection Fees

Data Collection - FY24 Fees (Effective July 1, 2023)

Light Scattering Services

Dynamic Light Scattering (DLS) Data Collection Fees

  Harvard
base price
Non-Harvard (base+F&A) Commercial
DLS - 1 - Setup Fee, per plate $275 $330 $660
Setup fee per plate, up to 48 samples, includes BSA control and 1 buffer control. In addition to per-sample fee.      
DLS - 2 - Sample Data Collection $80 $96 $192
Per sample fee, in duplicate wells, 5-10 acquisitions/scan, 2 scans/well, in addition to plate setup fee.      
DLS - 3 - Additional Replicate Sample $45 $54 $108
Per additional replicate on the same plate      
DLS - Small molecule aggregation analysis $570 $684 $1,368
Per plate, one scan/well.      

Static Light Scattering (SEC-MALS) Data Collection Fees

  Harvard
base price
Non-Harvard (base+F&A) Commercial
SEC-MALS - 1 - Setup Fee, per buffer $550 $660 $1,320
Per buffer, includes analytical column equilibration, BSA control, in addtion to per-sample fee.      
SEC-MALS - 2 - Sample Data Collection $250 $300 $600
Per sample injection on analytical column, 0.5 ml/min.      
SEC-MALS - 3 - Replicate Injection of Sample $125 $150 $300
Per replicate sample injection collected in the same sequence.      
SEC-MALS - dndc measurement $540 $648 $1,296
Per user-provided reagent.      

Mass Photometry (MP) Data Collection Fees

  Harvard
base price
Non-Harvard (base+F&A) Commercial
Mass Photometry - 1 - Setup Fee $370 $444 $888
Setup fee per calibration, per buffer, per FOV.      
Mass Photometry - 2 - Sample Data Collection $190 $228 $456
Per sample fee, in triplicate.      

Differential Scanning Fluorimetry Services

  Harvard
base price
Non-Harvard (base+F&A) Commercial
Prometheus - 1 - Setup Fee using NanoDSF, per capillary set $295 $354 $708
NanoDSF Setup fee per capillary set, up to 10 samples, includes lysozyme or BSA control. DSF on the Prometheus using protein fluorescence. In addition to per-sample fee.      
Prometheus - 2 - Sample Data Collection, in duplicate $85 $102 $204
NanoDSF Per sample fee, measured in duplicate, 2C/min, in addition to setup fee.      
Prometheus - 2P - Sample Data Collection, in duplicate, HIGH SENSITIVITY CAPILLARIES $110 $132 $264
NanoDSF Per sample fee, measured in duplicate, 2C/min, High Sensitivity Capillaries for low concentration      
Prometheus - 3 - Additional Replicate Sample $25 $30 $60
NanoDSF per additional replicate collected in same cassette.      
Prometheus - 3P - Additional Replicate Sample, HIGH SENSITIVITY CAPILLARIES $35 $42 $84
NanoDSF per additional replicate collected in same cassette, High Sensitivity Capillaries for low concentration.      
Prometheus - Buffer Optimization Screen $635 $762 $1,524
NanoDSF 96 conditions NaCl vs pH, 1 measurement each, 2C/min      
QuantStudio - 1 - Setup Fee using Sypro Orange, per plate $305 $366 $732
DSF Setup fee per plate, up to 30 samples, includes lysozyme control and 1 buffer control. DSF on the QuantStudio using SyproOrange protein stain. In addition to per-sample fee.      
QuantStudio - 2 - Sample Data Collection, in triplicate $75 $90 $180
DSF Per sample fee, measured in triplicate, 2C/min, in addition to setup fee.      
QuantStudio - Buffer Optimization Screen $485 $582 $1,164
DSF 96 conditions NaCl vs pH, 1 measurement each, 2C/min      

Circular Dichroism Services

  Harvard
base price
Non-Harvard (base+F&A) Commercial
CD - 1 - Scan Setup Fee $220 $264 $528
Setup fee per dataset (up to 20 scans), includes 1 buffer control. Additional buffers should be listed as samples.      
CD - 2 - Sample Data Collection CD Scan $140 $168 $336
Per sample, Far-UV 260-185 nm scan, 5-10 accumulations, in addition to setup fee.      
CD - 3 - Replicate Sample CD Scan $65 $78 $156
Per Replicate sample collected in the same dataset (or alternate temperature scan of existing sample).      
CD - thermal denaturation $515 $618 $1,236
Per sample, 20-95C scan, 1C interval, 1C/min rate, 30s hold, 1-3 wavelengths, includes CD scan at 20C.      

Chromatography Services

SEC Protein Purification Services - Preparative

 

  Harvard
base price
Non-Harvard (base+F&A) Commercial
SEC 10/300 - 1 - Setup Fee, per buffer $460 $552 $1,104
per buffer, includes column equilibration and gel filtration standards (up to 12 injections on a 10/300)      
SEC 10/300 - 2 - Sample Purification $200 $240 $480
SEC purification of one sample, per injection, up to 500 ul at 10 mg/ml.      
SEC 10/300 - 3 - Replicate purification $110 $132 $264
Repeat injection of another sample in the set.      
SEC 10/300 - Optional - Special conditions - 1a -Setup $205 $246 $492
Surcharge per setup, for low flow rate or other special condition.      
SEC 10/300 - Optional - Special conditions - 2a - Sample $60 $72 $144
Surcharge per sample, for low flow rate or other special condition      

 

FSEC Data Collection Services - Analytical

  Harvard
base price
Non-Harvard (base+F&A) Commercial
FSEC - 1 - Setup Fee, per buffer $270 $324 $648
Per buffer, includes 50 mm analytical column equilibration, BSA control, in addtion to per-sample fee.      
FSEC - 2 - Sample Data Collection $80 $96 $192
Per sample injection on analytical column, 0.5 ml/min.      
FSEC - 3 - Replicate Injection of Sample $50 $60 $120
Per replicate sample injection collected in the same sequence.      

Static Light Scattering (SEC-MALS) Data Collection Services - Analytical

  Harvard
base price
Non-Harvard (base+F&A) Commercial
SEC-MALS - 1 - Setup Fee, per buffer $550 $660 $1,320
Per buffer, includes analytical column equilibration, BSA control, in addtion to per-sample fee.      
SEC-MALS - 2 - Sample Data Collection $250 $300 $600
Per sample injection on analytical column, 0.5 ml/min.      
SEC-MALS - 3 - Replicate Injection of Sample $125 $150 $300
Per replicate sample injection collected in the same sequence.      
SEC-MALS - dndc measurement $540 $648 $1,296
Per user-provided reagent.      

General Services

  Harvard
base price
Non-Harvard (base+F&A) Commercial
Buffer Preparation 1L - PBS $70 $84 $168
Up to 1 L PBS buffer, filtered and degassed      
Buffer Preparation 1L - User Custom Buffer $165 $198 $396
Up to 1 L SEC buffer using reagents available at the CMI (phosphate, HEPES, Tris, NaCl reducing agent), filtered and degassed      
Buffer Exchange $100 $120 $240
Protein buffer exchange into PBS or standard CD buffer (e.g. to 10 mM Phosphate, 150 mM NaF for CD)      
Custom Protein Services Hourly Labor (as available) $135 $162 $324
Hourly Service Rate for custom protein services, in addition to consumables billed at cost.      

Example Project Fees

Example project details: Light Scattering analysis project for SEC-MALS of 2 proteins in one buffer system, with a replicate injection of each sample. Project setup includes column equilibration (12+ column volumes) into user-provided buffer and a BSA control experiment. 

line item Qty Harvard Fee
SEC-MALS setup  1 $550
SEC-MALS data collection 2 2x $250
SEC-MALS replicate injection 2 2x $125
Total   $1,300

Nanobody Selection Services (ACADEMIC ONLY)

To learn more about nanobody selections at the CMI, visit our Nanobody Services page.

Fees for Nanobody selections cover supplies and labor and are assessed for completed stages in the selection, regardless of final experimental outcome of the selection. 

  Harvard base price External Academic (base+F&A)
Antigen Purification by SEC $660 $792
Required, if not performed by user    
Basic Yeast Surface Display Nanobody Selection Campaign $8,650 $10,380
Includes 2 rounds MACS, 2 rounds FACS, clonal isolation, NGS of enriched library, delivery of any sequences or clones produced.    
Full Yeast Surface Display Nanobody Selection Campaign $9,840 $11,808
Includes Basic Yeast Surface Display Selection Campaign plus cloning into pET26b for periplasmic bacterial expression, for up to 20 isolated clones.    
Nanobody Expression and Purification $4,410 $5,292
Requires Full Yeast Surface Display Selection. Includes small scale periplasmic expression, purification and FSEC, then large scale express and purification of up to 3 Nb, if soluble.    

 

Addresses

General Inquiries
and Questions

 
Kelly Arnett, Director
cmi@hms.harvard.edu
617-432-5004

 

CMI Contact Form

Questions about PPMS administration:

PPMS_admin@hms.harvard.edu

Shipping Address: 

Harvard Medical School
240 Longwood Ave.
Building C, Room 309
Boston, MA 02115

 

Do not ship samples without receiving specific instructions from the CMI, including an estimated date for data collection. 

  • We must receive a CMI User Agreement and PO before scheduling service.

CMI Billing Address:

Harvard University 
Central Accounts Receivable 
P.O. Box 4999 
Boston, MA 02212

Harvard Accounts Receivable


ar_customers@harvard.edu

Pay a Bill - AR portal

question about a bill:
Contact: Lola Yao 
Lola_Yao@hms.harvard.edu