Nanobody Service Fees
- Limited Nanobody Selection Services are offered at the CMI to academic users.
- Service fees are based on labor and supplies costs, and will be charged for all completed stages of a selection campaign, regardless of experimental outcome.
- Before submitting samples for data collection, users must approve the estimated charges and be given a date and time for sample delivery.
- External Users will also be required to submit a PO and a signed CMI Nanobody User Agreement.
Service Fees - FY26 (July 1, 2025 - June 30, 2026)
| Service Name | description | Harvard Base Price | External Academic (base+F&A) |
|---|---|---|---|
Antigen Purification by SEC | Required, if not performed by user | $695.00 | $869.40 |
Basic Yeast Surface Display Nanobody Selection Campaign | Includes 2 rounds MACS, 2 rounds FACS, clonal isolation, NGS of enriched library, delivery of any sequences or clones produced. | $9,265.00 | $11,623.50 |
Full Yeast Surface Display Nanobody Selection Campaign | Includes Basic Yeast Surface Display Selection Campaign plus cloning into pET26b for periplasmic bacterial expression, for up to 20 isolated clones. | $10,540.00 | $13,230.00 |
Nanobody Expression and Purification | Requires Full Yeast Surface Display Selection. Includes small scale periplasmic expression, purification and FSEC, then large scale express and purification of up to 3 Nb, if soluble (6 L in total). | $4,710.00 | $5,934.60 |
Binding - Yeast Surface Dose Response | per Nb/antigen, 12 data points. | $905.00 | $1,140.30 |
Binding - Nanobody Pulldown Assay | Streptavidin pull-down on magnetic beads, per Ag/Nb | $585.00 | $730.80 |
Service Fees - FY27 (Effective July 1, 2026)
| Service Name | description | Harvard Base Price | External Academic (base+F&A) |
|---|---|---|---|
Antigen Purification by SEC | Required, if not performed by user | $705.00 | $881.25 |
Basic Yeast Surface Display Nanobody Selection Campaign | Includes 2 rounds MACS, 2 rounds FACS, clonal isolation, NGS of enriched library, delivery of any sequences or clones produced. | $9,430.00 | $11,787.50 |
Full Yeast Surface Display Nanobody Selection Campaign | Includes Basic Yeast Surface Display Selection Campaign plus cloning into pET26b for periplasmic bacterial expression, for up to 20 isolated clones. | $10,715.00 | $13,393.75 |
Nanobody Expression and Purification | Requires Full Yeast Surface Display Selection. Includes small scale periplasmic expression, purification and FSEC, then large scale express and purification of up to 3 Nb, if soluble (6 L in total). | $4,840.00 | $6,050.00 |
Binding - Yeast Surface Dose Response | per Nb/antigen, 12 data points. | $910.00 | $1,137.50 |
Binding - Nanobody Pulldown Assay | Streptavidin pull-down on magnetic beads, per Ag/Nb | $595.00 | $743.75 |