Grant Support

Active and potential CMI users and labs may request a letter of support for grant applications, from the CMI Core director, Kelly Arnett.

General Description of CMI Resources

The Center for Macromolecular Interactions at Harvard Medical School (CMI) provides scientific consultation, training and access to shared biophysical equipment for the characterization of macromolecules and their complexes. Instruments at the CMI include a Microcal ITC200 for Isothermal Titration Calorimetry (ITC), a Cytiva Biacore T200 for Surface Plasmon Resonance (SPR), a Sartorius (ForteBio) Octet RED384 for Biolayer Interferometry (BLI), a NanoTemper Technologies Monolith NT.115pico for MicroScale Thermophoresis (MST), a Tecan Spark Multimode Plate Reader, a Life Technologies Quant Studio 6 and a NanoTemper Prometheus NT.Plex for protein thermal shift analysis by Differential Scanning Fluorimetry (DSF), a Jasco J-1500 spectropolarimeter for Circular Dichroism (CD), a Wyatt DynaPro Plate Reader III for Dynamic Light Scattering (DLS), an analytical Size Exclusion Chromatography system with Wyatt Dawn Heleos II Multi-Angle Light Scattering detector for SEC-MALS, a Refeyn TwoMP instrument for Mass Photometry and a Cytiva AKTA Pure for Fast Protein Liquid Chromatography (FPLC). These instruments provide several orthogonal methods for measuring protein/protein and protein/ligand interactions and for characterizing biophysical properties and protein quality.  

Since launch of the CMI in early 2015, over 250 scientific publications in high impact journals have featured work performed at the CMI (cmi.hms.harvard.edu/publications).  To offset some of the costs associated with instrument maintenance and operation, all CMI users are charged fees for instrument access and training. CMI fees are reevaluated annually and published on the website (cmi.hms.harvard.edu/fees).

 

Please let us know if you get a grant to use CMI technologies!

For information on access fees, policies and getting started at the CMI, see the CMI Access Page.