Can I get the CMI Yeast Surface Display Nanobody Library to perform my own selections?

 

For Nanobody selections, the CMI currently uses a synthetic yeast display library, developed in the Kruse lab, a based on a consensus framework derived from llama antibody genes with variable complementary determining region loops (CDRs) designed from known nanobody structures.1

This library is available for non-profit research from Kerafast: EF0014-FP. For-profit organizations can license the library from the Harvard Office of Technology Development.

  1. McMahon, C. et al.Yeast surface display platform for rapid discovery of conformationally selective nanobodies. Nat Struct Mol Biol25,289–296 (2018).