Circular Dichroism (CD)
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The Jasco J-1500 measures Circular Dichroism and can be used to measure protein secondary structure and thermal stability.
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17 results for "Circular Dichroism"
17 results for "Circular Dichroism"
Circular Dichroism and Isothermal Titration Calorimetry to Study the Interaction of α-Synuclein with Membranes
Journal Article
α-Synuclein's physiology and pathology have been linked by numerous reports to its ability to bind and remodel membranes, especially at synaptic terminals. It is therefore critical for researchers investigating the determinants of these interactions to...
Circular Dichroism Service Fees
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Limited Data Collection Services are offered for select CMI Technologies. Before submitting samples for data collection, users must approve the estimated charges and be given a date and time for sample delivery. External Users will also be required to...
CD Services
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In addition to instrument training, the CMI is now offering basic protein Circular Dichroism Data Collection services, including Far-UV scan and thermal denaturation experiments. CMI CD Instrument: Jasco J-1500 Protein Far-UV Scan for Secondary Structure...
How pure does my protein sample need to be for analysis by DSF, CD or light scattering?
FAQ
The more pure your sample is, the easier it is to interpret the results, as contaminating proteins may contribute to your overall signal in bulk measurements.
Differential Scanning Fluorimetry (DLS), Circular Dichroism (CD) and Dynamic Light Scattering...
New CMI services
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The CMI is now offering protein data collection services, including light scattering by SEC-MALS and DLS, differential scanning fluorimetry and circular dichroism, as well as nanobody production services using yeast surface display libraries developed in...
N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation
Journal Article
A switch in the conformational properties of α-synuclein (αS) is hypothesized to be a key step in the pathogenic mechanism of Parkinson's disease (PD). Whereas the beta-sheet-rich state of αS has long been associated with its pathological aggregation in...
Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity
Journal Article
Despite two decades of research, the structure-function relationships of endogenous, physiological forms of α-synuclein (αSyn) are not well understood. Most in vitro studies of this Parkinson's disease-related protein have focused on recombinant αSyn that...
Center for Macromolecular Interactions
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The Center for Macromolecular Interactions The Center for Macromolecular Interactions (CMI) in the department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School has a mission to enhance basic research in the HMS community by...
Grant Support
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Active and potential CMI users and labs may request a letter of support for grant applications, from the CMI Core director, Kelly Arnett . New users should contact the CMI to discuss you project and getting started at the CMI. Existing CMI user labs may...