Publications
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252 results
252 results
2026
Microporous particles with hydrophobic internal surfaces and hydrophilic external surfaces can dramatically enhance the gas-carrying capacity and gas transfer kinetics of aqueous solutions. Pure-silica zeolites are particularly well suited to forming...
2025
Gram-negative bacterial pathogens rely on a dynamic peptidoglycan (PG) cell wall to maintain viability, withstand antibiotic stress, and interface with their hosts. Although numerous PG-active enzymes and PG-sensing proteins have been identified, the...
Monoclonal antibodies (mAbs) are the single largest class of therapeutics used in various indications including oncology, immunology, and neurology. Given their high prevalence, the development of subcutaneously administrable mAb formulations via...
Four seasonal endemic human coronaviruses (EhCoVs), HKU1-CoV, OC43-CoV, 229E-CoV, and NL63-CoV, are culprits of mild upper respiratory and periodic severe diseases in vulnerable populations. Despite their prevalence, understanding EhCoVs’ antigenic and...
Hyaluronic acid (HA) binds the transmembrane glycoprotein cluster of differentiation-44 (CD44), a highly expressed surface receptor that plays a critical role in tumor growth, invasion, and metastasis. Approaches to target CD44 utilize biologically...
Epstein-Barr virus (EBV) uses a biphasic lifecycle, switching between latent and lytic phases to persistently infect most adults. Latency is observed in most tumor cells of the 200,000 EBV-associated cancers/year. EBV reactivation is increasingly...
DNA methyltransferase 3A (DNMT3A) is a DNA methyltransferase that is recurrently mutated in hematological malignancies and developmental disorders. The most prevalent mutation, R882H, compromises DNMT3A activity in a dominant-negative manner, but its...
Animal innate immunity evolved from ancient pathways in bacterial anti-phage defense. How bacterial immune components were first acquired and adapted within eukaryotic cells remains poorly understood. Here we identify a complete cGLR-STING signaling axis...
The transcription of ebolavirus (EBOV) genomes is a major checkpoint in the viral life cycle. Altering the transcription regulatory signal (TRS), an RNA hairpin that forms in the 3' leader sequence of EBOV, affects transcription in a VP30-dependent manner...
The cytosolic iron-sulfur cluster assembly (CIA) targeting complex maturates over 30 cytosolic and nuclear Fe-S proteins, raising the question of how a single complex recognizes such a diverse set of clients. The discovery of a C-terminal targeting...
Mammalian SWI/SNF (BAF) chromatin remodeling complexes modulate DNA accessibility and gene expression, however, the mechanisms by which these master regulatory complexes are targeted on chromatin remain incompletely understood. Here, we define SWIFT (SWI...
The temporospatial distribution of proteins within cilia is regulated by intraflagellar transport (IFT), wherein molecular trains shuttle between the cell body and cilium. Defects in this process impair various signal-transduction pathways and cause...