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CMI Seminar
Mass Photometry – a new tool to study biomolecules
Speaker: Gael Nicolas, Refeyn, Inc.
A range of techniques has been developed to characterise proteins and their interactions, but structural and dynamic heterogeneity remain a fundamental challenge. Mass photometry enables accurate mass measurement of single molecules in solution, in their native state and without the need for labels, opening new possibilities for bioanalytics and research into biomolecular functions. Mass photometry is based on interferometric scattering microscopy, attaining mass information of biomolecules in solution by measuring the light that they scatter. This unique technology can be used to detect and characterize proteins, nucleic acids, lipids and / or sugars, providing structural data (oligomeric states and modifications), sample heterogeneity assessments, and functional information (quantifying molecular interactions) – all in a matter of minutes, using very little sample. Due to its unique benefits, mass photometry addresses a major unmet need for more efficient analytical tools and will ultimately help accelerate science and the discovery and development of new therapeutics.